The principal cytochrome P450 isoenzyme involved seems to become CYP2E1, with CYP1A2 and CYP3A4 as supplemental pathways. Roughly 85% of an oral dose appears in the urine in just 24 hours of administration, most given that the glucuronide conjugate, with modest quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity details.